
Research Clinical Trials
AFIRM-Funded Clinical Trials - The AFIRM conducts clinical trials so that research can be translated from the laboratory to the clinic. For more information, click on the links below.
Current Clinical trials:
AFIRM II Clinical Trials
Extremity Injury Treatment
Facial/Skull Reconstruction
- CF-06: An Explorative Clinical Prospective Feasibility Study to Address the Effectiveness and Safety of Calciumphosphate/Poly(lactic-co-glycolic-acid) for Bone Augmentation in Maxillary Sinus Floor Elevation Surgery
– conducted at Radboud University in the Netherlands
- CF-11: A Phase I Open-Label Study Evaluating the Safety of Acellular Adipose Tissue (AAT), a Novel Soft Tissue Reconstruction Solution, in Healthy Volunteers
Hand and Face Transplantation
- CTA-09: Vascularized Composite Allotransplantation of the Hand (HandCTA)
- CTA-10: Face Transplantation
- CTA-11: Withdrawal of Immunosuppression in Recipients of Face and Extremity Transplants
Skin Injury Treatment
- SR-06: StrataGraft® Skin Tissue as an Alternative to Autografting Full-thickness Complex Skin Defects
– StrataTech Corporation - Phase II trial ongoing.
- SR-08: Reducing Side Effects of Autologous Skin Tissue Harvesting
– Massachusetts General Hospital
- ER-11: Feasibility Study for Fibroblast Autologous Skin Grafts
– Johns Hopkins University
AFIRM I Trials
Limb and Digit Salvage
- WFPC 4.4.2: Human Upper Extremity Allotransplantation
Burn Repair
- RCCC 4.7.2: Safety and Efficacy Study of Autologous Engineered Skin Substitute to Treat Partial- and Full-Thickness Burn Wounds
- RCCC 4.2.7: ReCell® Combined With Meshed Skin Graft in the Treatment of Acute Burn Injuries
- RCCC 4.2.7: StrataGraft® Skin Tissue as an Alternative to Autografting Deep Partial-Thickness Burns
– completed
Craniofacial Reconstruction
- RCCC 4.3.1b: Face Transplantation Clinical Trial
(Cleveland Clinic)
- WFPC 4.1.4/4.1.5: A Study to Evaluate the Results of Facial Soft Tissue Reconstruction in Patients Who Have Suffered Traumatic Injury (BTI)
– completed
- WFPC 4.1.4/4.1.5: Structural Fat Grafting for Craniofacial Trauma: Repeat Fat Grafting Injection-5 Subject Cohort (BTI Plus Up)
– completed
- WFPC 4.1.4/4.1.5: Structural Fat Grafting for Craniofacial Trauma Using Manual Technique for Processing Fat Graft Material (BTI++)
– completed
Limb Reconstruction, regeneration or transplantation
- WFPC 4.1.4/4.1.5: Evaluating Safety and Efficacy of TOL101 Induction Versus Anti-Thymocyte Globulin to Prevent Kidney Transplant Rejection
Wound Healing without Scarring
- RCCC 4.7.3: Autologous Fat Transfer for Scar Prevention and Remodeling
- WFPC 4.5.9: A Study of a Novel Silicone Dressing to Minimize Scar Formation (REFINE)
– completed
- WFPC 4.5.9: Investigation of a Novel Silicone Dressing to Maximize the Outcomes of Scar Revision Procedures (IMPROVE)
– completed
Several of these studies are still recruiting participants.
Last Modified Date: 09 Sep 2016